Sonodynamic and magnetic targeting platelet-membrane biomimetic platform for glioblastoma therapy.

ABSTRACT:

Background

Due to the presence of the blood-brain barrier, the efficacy of chemotherapy for glioblastoma has remained suboptimal. Even drugs capable of crossing the BBB, such as temozolomide, exhibit limited therapeutic outcomes owing to insufficient targeting.

Methods

Here, we developed a platelet membrane-hybridized biomimetic microbubble by loading superparamagnetic iron oxide and temozolomide-embedded polymers, constructing an ultrasound-controlled platelet membrane-inspired magnetic targeting drug delivery platform (ST-PM). Extensive in vitro and in vivo experimental results demonstrate that ST-PM exhibits inhibitory effects on glioblastoma under the combined action of a magnetic field and focused ultrasound.

Results

The results demonstrated that ST

SUBMITTER: Zou S 

PROVIDER: S-EPMC12500637 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature