Differential susceptibility to prenatal stress exposure in serotonin transporter-deficient female mice-an epigenetic exploration.

ABSTRACT:

Introduction

Early-life stress exposure has been linked to an increased risk for the onset of mental disorders. As another factor, an individual's genetic make-up may also tip the scale towards health or disease, with certain genetic variants mediating differential susceptibility towards the effects of early-life stress or other experiences. The current study investigated the molecular foundation of individual variation in the response to prenatal stress (PS) exposure in wildtype mice as well as in mice deficient for the serotonin (5-hydroxytryptamine, 5-HT) transporter (5-HTT).

Methods

To meet this end, wildtype C57BL6/J dams were mated with 5-Htt+/- C57BL6/J males, after which they were exposed to restraint stress during the last part of gestation. In adulthood, female 5-H

SUBMITTER: Weidner MT 

PROVIDER: S-EPMC12500653 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature