Properties of MSC populations enriched in CD146-expressing MSCs - a systematic review and meta-analysis of <i>in vitro</i> studies.

ABSTRACT:

Introduction

Mesenchymal stromal cells (MSCs) are promising therapeutic candidates in regenerative medicine and the treatment of inflammatory diseases, yet their therapeutic effectiveness is limited by their heterogeneity. Clinical outcomes may be enhanced by isolating MSC subpopulations based on surface markers, including CD146. Many in vitro studies have investigated various cellular properties of MSC subpopulations that are enriched in CD146-expressing cells (CD146^Enr.) compared to those that are depleted in CD146-expressing cells (CD146^Depl.) and/or heterogeneous populations. Hence, this review aimed to systematically explore the basic cellular characteristics of MSC populations with different levels of CD146-expressing cells.

Methods

Two electronic

SUBMITTER: Behm C 

PROVIDER: S-EPMC12500659 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature