The active constituent of pine needle oil, bornyl acetate, suppresses NSCLC progression by inhibiting the PI3K/AKT/ABCB1 signaling axis.

ABSTRACT:

Introduction

Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related mortality worldwide. Although targeted therapies and immunotherapies have improved treatment outcomes, the development of drug resistance continues to limit clinical efficacy. This study aims to explore the potential therapeutic effects and molecular mechanisms of pine needle oil and its key bioactive component, bornyl acetate (BA), in NSCLC.

Methods

The anti-cancer activity of BA was evaluated in vitro using two NSCLC cell lines, A549 and NCI-H460. Cell proliferation, invasion, migration, colony formation, and apoptosis were assessed. Mechanistic studies focused on the PI3K/AKT signaling pathway and ABCB1 expression levels. The AKT agonist SC79 was used to rescue phenotypic effects. In vivo

SUBMITTER: Wu J 

PROVIDER: S-EPMC12500681 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature