Regulation of aquaporin-2 using traditional Chinese medicine in water balance disorders: a literature review.

ABSTRACT: Aquaporin-2 (AQP2) is a critical protein involved in water metabolism. It is primarily located in the renal collecting duct cells' apical plasma membranes and intracellular vesicles and regulates the movement of water into and out of cells. It plays a pivotal role in maintaining fluid balance, and its dysregulation is associated with conditions such as hypertension and heart failure, which contribute to cardiovascular disease progression. AQP2 has garnered significant attention as an emerging therapeutic target. Traditional Chinese medicine (TCM) has demonstrated efficacy in treating water balance disorders, although its underlying mechanisms remain elusive. The discovery of AQP2 and its association with water metabolism provides an opportunity for TCM to explore these mechanisms more intu

SUBMITTER: Chang Y 

PROVIDER: S-EPMC12500708 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature