Plasma fibrinogen level and acute aortic dissection prognosis-insights from a two-center cohort study.

ABSTRACT:

Objective

The relationship between plasma fibrinogen level (PFL) and prognosis of acute aortic dissection (AAD) are not well defined. The present study aimed to assess the effect of PFL on AAD prognosis through a two-center study and meta-analysis.

Methods

A two-center cohort study was carried out in the two hospitals from Shantou and Xi'an cities. 1981 patients with AAD, admitted from 2012 to 2021, were included and followed up by clinical interview and telephone. The primary follow-up outcomes were 30-day mortality and long-term mortality. The relationship between PFL and all-cause mortality was identified. Further, meta-analysis was performed using our data and open access data.

Results

The median follow-up time for the study cohort was 21.6 months (interquartile r

SUBMITTER: Xiao J 

PROVIDER: S-EPMC12500716 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature