Development and validation of an intraoperative perforation prediction scoring system for endoscopic resection of gastric gastrointestinal stromal tumors.

ABSTRACT:

Background

Endoscopic resection (ER) is a minimally invasive treatment for gastric gastrointestinal stromal tumors (gGISTs), but intraoperative perforation risk remains a significant concern. Currently, no validated tools exist to preoperatively identify high-risk patients. This study aimed to develop and validate a practical scoring system for predicting intraoperative perforation during ER of gGISTs.

Methods

A multi-center retrospective study analyzed 1,124 patients undergoing ER for gGISTs, divided into training (n = 496), internal validation (n = 212), and external validation cohorts (n = 416). Independent risk factors for intraoperative perforation were identified through univariate and multivariate logistic regression and weighted by regression coefficients to construc

SUBMITTER: He B 

PROVIDER: S-EPMC12500726 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature