Predictors of Methylphenidate response in children and adolescents with ADHD: the role of sleep disturbances.

ABSTRACT: Sleep Disturbances (SD) have been linked to children and adolescents with ADHD, impacting its progression and outcomes. Methylphenidate (MPH), a commonly used stimulant medication for ADHD treatment, has been observed to potentially influence SD as a side effect, while SD can in turn potentially affect the response to MPH. This study aimed to explore the potential role of SD on MPH response in children and adolescents with ADHD. At this aim, 43 children and adolescents with ADHD received a single dose of MPH and were assessed for attention before and after medication administration. As expected, the administration of MPH resulted in improved attention levels. Our data indicate that patients with higher SD experienced greater benefits from the medication, stabilizing Reaction Times Variabil

SUBMITTER: D'Aiello B 

PROVIDER: S-EPMC12500731 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature