Enucleation for insulinoma: consolidating evidence through systematic review and meta-analysis.

ABSTRACT:

Background

Pancreas-preserving procedures such as enucleation (EN) are indicated for select patients with insulinomas. Despite the increasing popularity of EN, no consensus has been reached on the preferred surgical approach for the management of insulinomas. The aim of this meta-analysis of proportions is to evaluate the safety and efficacy of EN for patients with pancreatic insulinoma.

Methods

Cochrane, Embase, PubMed, Scopus, and Web of Science were searched from database inception to December 2023. The pooled mean and proportions were analyzed using a random-effects model. The review was registered prospectively with PROSPERO (CRD42024492786).

Results

Twenty-one studies with 803 patients met the inclusion criteria. The pooled mean tumor diameter was 1.5 cm (95%CI:

SUBMITTER: Alogakos M 

PROVIDER: S-EPMC12500762 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature