Impact of preoperative biliary drainage on outcomes of pancreaticoduodenectomy in severe hyperbilirubinemia.

ABSTRACT:

Background

Optimal management of patients with severe hyperbilirubinemia (> 14.6 mg/dL) undergoing pancreaticoduodenectomy remains controversial.

Methods

Single-center retrospective study of 665 pancreaticoduodenectomies (2007-2024). Patients were stratified: no preoperative biliary drainage (PBD) with high (> 14.6mg/dL, n = 83) or low (< 14.6mg/dL, n = 312) bilirubin; PBD for low bilirubin (n = 140); PBD for high bilirubin (n = 113).

Primary outcomes

90-day mortality, morbidity, and specific complications.

Results

Ninety-day mortality was significantly higher in non-PBD patients with high bilirubin (13.3%) compared to other groups (2.9-5.7%, p = 0.001). Overall morbidity was also higher in this group (29.0% vs. 12.8-20.7%, p < 0.001). While PBD groups showed h

SUBMITTER: Kanani F 

PROVIDER: S-EPMC12500813 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature