Hospital operative volume impacts surgical outcomes for patients with T4 rectal cancer following neoadjuvant chemoradiation: a national cancer database analysis.

ABSTRACT:

Background

Hospital operative volume has been shown to impact outcomes in complex oncologic surgeries. However, the effect of hospital volume on surgical quality and survival in patients with T4 rectal cancer following neoadjuvant chemoradiation, including total neoadjuvant therapy (TNT), remains unclear. This study evaluates the relationship between hospital volume and the achievement of optimal surgical resection (OSR) in patients with T4 rectal cancer and its subsequent impact on postoperative outcomes and survival.

Methods

A retrospective cohort study was conducted using the National Cancer Database (NCDB) from 2004 to 2021. Patients with T4 rectal cancer undergoing curative-intent oncologic resection following neoadjuvant chemoradiation were included. Hospitals were cat

SUBMITTER: Simon EF 

PROVIDER: S-EPMC12500830 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature