Correspondence between sleep patterns and anhedonia in adult male mice exposed to early-life stress.

ABSTRACT: Early-life stress (ELS) can produce long-lasting effects that increase the risk for mood and anxiety disorders. Transdiagnostic symptoms include anhedonia (reduced reward sensitivity) and sleep disruption, both of which are quantifiable via objective endpoints that can be utilized across species. Here we used a mouse model for ELS-exposure to juvenile chronic social defeat stress (jCSDS)-together with translationally-applicable endpoints to examine correspondence between sleep patterns and anhedonia. These initial studies focused on males, which typically show robust defeat-induced anhedonia phenotypes. Exposure to jCSDS produced reductions in open-field social behavior, an endpoint commonly used in mice to quantify stress effects, during adulthood. Mice were then implanted with wireless t

SUBMITTER: Hall AG 

PROVIDER: S-EPMC12500860 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature