Harnessing platinum(IV) prodrugs as versatile photoinitiators and photocrosslinkers for multifunctional hydrogels and protein labeling.

ABSTRACT: Photoresponsive molecules have revolutionized the fields of chemistry, biology, and medicine by enabling precise spatiotemporal control through external light stimuli. While extensive efforts have been employed to investigate the photochemical properties of Pt(IV) coordination complexes, their biomedical applications are still limited to chemotherapeutic functions. Herein, the photochemistry of clinical drug-based Pt(IV) prodrugs is investigated. Surprisingly, Pt(IV) complexes, rather than their Pt(II) counterparts, exhibit rapid photolysis upon irradiation at 365 nm, generating various reactive species including ROS and platinum radicals. Exploiting these unique photolysis products, we demonstrate alternative uses of Pt(IV) prodrugs as photoinitiators, enabling facile fabrication of multi

SUBMITTER: Xu J 

PROVIDER: S-EPMC12500910 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature