Sex-specific disruptions in the developmental trajectory of anxiety-like behaviors due to prenatal cannabidiol exposure.

ABSTRACT: Many pregnant women use cannabidiol (CBD) as a natural remedy to alleviate symptoms such as nausea, insomnia, anxiety, and chronic pain. As much as 20% of pregnancies in the USA and Canada may involve the use of CBD-only products. CBD crosses the placenta and may affect fetal development, potentially leading to neuropsychiatric conditions later in life. Given the limited understanding of the effects of CBD during pregnancy, we adopted a longitudinal approach to investigate the neurodevelopmental trajectory associated with prenatal CBD exposure. Pregnant mice were administered 3 mg/kg CBD from gestational days 5 to 18. At early adolescence, offspring displayed sex-specific behavioral changes. Females, but not males, exhibited a complex anxiety-like phenotype during the elevated plus maze ta

SUBMITTER: Iezzi D 

PROVIDER: S-EPMC12500939 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature