Multi-connectomics underpin emotional dysfunction in mouse exposed to simulated space composite environment.

ABSTRACT: Long-duration space exploration, including missions to the Moon and Mars, demands strategies to preserve astronauts' emotional well-being for optimal performance. This study combines behavioral phenotyping, multimodal MRI, in vivo calcium imaging, and brain-wide genomics to bridge macroscopic brain function with mesoscopic neural activity and microscopic genetic processes, providing a dynamic characterization of the mouse connectome under simulated spaceflight conditions. We observed a reduction in gray matter volume, particularly in the prefrontal cortex, with prolonged exposure. Simulated space composite environment (SSCE) disrupted multi-scale functional connectivity and altered the macro-organizational functional gradient, reversing the relationship between brain function and emotional

SUBMITTER: Liang R 

PROVIDER: S-EPMC12500946 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature