Fallopian tubes influences sperm selection and fertilization success.

ABSTRACT: This study investigates the proteomic profile of the fallopian tube following exposure to human sperm, with a focus on its role in sperm capacitation, final sperm maturation, successful fertilization, and early embryonic development. Twenty reproductive-age women undergoing hysterectomy during the luteal phase were divided into two groups. The control group was instructed to abstain from intercourse for at least one week prior to surgery. The case group was instructed to have intercourse 24 to 48 h before surgery, ensuring intravaginal ejaculation. A 1 cm segment of the ampullary region of the fallopian tube was collected. Proteomic analysis was performed using a multiplexed tandem mass tag (TMT)-based proteomics approach. Western blot analysis was used to validate the data. A total of 90

SUBMITTER: Vatankhah M 

PROVIDER: S-EPMC12500959 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature