Salivary mitochondrial DNA is associated with biomarkers of Alzheimer's disease in cognitively normal older adults.

ABSTRACT: A significant body of evidence suggests that mitochondrial dysfunction plays a key role in the development and progression of Alzheimer's disease (AD). However, the absence of peripheral biomarkers for mitochondrial dysfunction limits its clinical applicability. Mitochondrial DNA (mtDNA) copy number, a proxy for mitochondrial function, has shown promise in detecting early stages of AD and predicting AD risk in cerebrospinal fluid (CSF) and blood, respectively. Surprisingly, recent studies have identified mtDNA molecules in human saliva, but their relationship with AD remains unexplored. Here, we investigated potential associations between salivary mtDNA copy number and cortical amyloid-β (Aβ) load measured with PET, and blood AD markers measured with ultrasensitive single molecule array (S

SUBMITTER: Cantero JL 

PROVIDER: S-EPMC12501003 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature