Inflammatory and MRI perfusion biomarkers in predicting persistence of depression: a 6-month Longitudinal Study.

ABSTRACT: Systemic inflammation has been linked with major depressive episode (MDE) severity and treatment-resistant depression (TRD), but not for all patients. Brain mechanisms underlying these processes are still under investigation. Objectives: based on an integrative approach, we aimed at identifying clinical, inflammatory and perfusion markers predictive of depression outcome at 6 months. We conducted a longitudinal study including 60 patients diagnosed with MDE, focusing on anxiety and anhedonia as main clinical candidates, inflammation (C-Reactive Protein - CRP) and cerebral blood flow (CBF) using pseudo-continuous arterial spin labeling (pcASL) MRI. A bootstrapped elastic net regression analysis was conducted including clinical, CBF and inflammation as predictors with depressive severity at

SUBMITTER: Batail JM 

PROVIDER: S-EPMC12501006 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature