Adolescent methamphetamine exposure drives neuroinflammation and aberrant neurogenesis linked to anxiety and cognitive impairments in adult mice.

ABSTRACT: The adolescent brain, characterized by its high plasticity, is particularly vulnerable to substance abuse, leading to long-term impacts on brain function and behavior. Methamphetamine (METH), a potent psychostimulant, is associated with severe neurological and psychiatric consequences. While most studies focus on METH exposure in adulthood, little is known about the effects of adolescent METH exposure. In this study, we explored the long-term effects of adolescent METH exposure on brain function and behavior in adulthood using a mouse model. Mice were administered METH for 8 days during adolescence, and their behavior was analyzed in adulthood. METH-exposed mice (METH mice) displayed anxiety-like behaviors, cognitive decline, and increased microglial numbers in the medial prefrontal cortex

SUBMITTER: Ito A 

PROVIDER: S-EPMC12501007 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature