Early treatment-related changes in dorsolateral prefrontal cortex activity and functional connectivity as potential biomarkers for antidepressant response in major depressive disorder.

ABSTRACT: Cognitive deficits are prevalent in major depressive disorder (MDD). Given that the dorsolateral prefrontal cortex (DLPFC) is a crucial region within the executive control network, its activity and functional connectivity (FC) may serve as potential indicators of antidepressant response. This prospective cohort study recruited 115 MDD patients and 43 healthy controls. Psychological assessments, electroencephalogram and event-related potential recordings were performed at baseline and 1 week after venlafaxine treatment, with a 12-week follow-up. Independent sample t-tests and Mann-Whitney U tests analyzed group differences, while linear mixed-effects models and logistic regression evaluated associations between DLPFC activity/FC changes and clinical outcomes. The MDD group showed significan

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12501012 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature