Lactate-mediated histone lactylation promotes melanoma angiogenesis via IL-33/ST2 axis.

ABSTRACT: The pathogenesis of cancer is complicated, with metabolic reprogramming and angiogenesis as the hallmark characteristics. Recent reports have unveiled that the glycolytic metabolite lactate could modify histone lactylation to epigenetically regulate gene expressions and biological processes in cancer, while the effect on tumor angiogenesis remains elusive. By taking advantage of melanoma as the model, we first proved that lactate and histone lactylation facilitated melanoma angiogenesis both in vitro and in vivo. Then, through RNA-sequencing and a series of biochemical assays, we found that lactate promoted the transcription of suppression of tumorigenicity 2 (ST2) in tumor-associated endothelial cells via the enhancement of histone lactylation at its promoter, so that to increase the resp

SUBMITTER: Zhao M 

PROVIDER: S-EPMC12501017 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature