Pharmacokinetic and phytochemical screening of Allium subhirsutum leaves for antimicrobial and anti-inflammatory properties.

ABSTRACT: This study aimed to screen the phytochemical composition of the leaves of Allium subhirsutum L. methanolic extract (ASE) by Gas Chromatography-Mass Spectrometry (GC-MS). Furthermore, the antioxidant, antibacterial and anti-inflammatory effects were examined using combined approaches: in silico, in vitro and in vivo on carrageenan-induced acute inflammation in rats. Inflammatory biomarkers (C-reactive protein and fibrinogen) oxidative injury parameters (thiobarbituric acid reactive substances, advanced oxidation of protein products, catalas, superoxide dismutase, and glutathione peroxidase) levels were assessed in the inflamed paws and compared to controls. The identified compounds in ASE possessed acceptable pharmacokinetic and ADMET (for absorption, distribution, metabolism, excretion and

SUBMITTER: Badraoui R 

PROVIDER: S-EPMC12501031 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature