Endometrial cancer progression driven by PTEN-deficiency requires miR-424(322)^~503.

ABSTRACT: Endometrial cancer is the most frequent type of cancer in the female reproductive tract. Loss-of-function alterations in PTEN, leading to enhanced PI3K/AKT activation, are among the most frequent molecular alterations in endometrial cancer. Increased PI3K/AKT signaling resulting from PTEN loss promotes cellular proliferation and confers resistance to TGFβ-mediated apoptosis, a key regulator of endometrial homeostasis. In this study, we have analyzed the role of miRNAs in driving these altered cellular responses. A comprehensive transcriptomic analysis of miRNA expression revealed the upregulation of several miRNAs caused by PTEN deficiency and/or TGFβ stimulation. The miR-424(322)^~503 cluster drew our attention due to its involvement in regulating apoptosis and proliferation. Ho

SUBMITTER: Vidal-Sabanes M 

PROVIDER: S-EPMC12501053 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature