Tumor-draining lymph nodes respond to immune checkpoint inhibition and orchestrate tumor immune remodeling.

ABSTRACT:

Background

Immune checkpoint inhibitors have traditionally been understood to exert their effects primarily within the tumor microenvironment, particularly targeting CD8 + T cells. However, recent studies have highlighted a pivotal role of tumor-draining lymph nodes in mediating responses to immune checkpoint inhibitor therapy. This study aimed to elucidate the specific mechanisms by which tumor-draining lymph nodes respond to immune checkpoint inhibitor therapy and regulate the tumor microenvironment in human colorectal cancer.

Methods

We performed single-cell RNA sequencing and T cell receptor sequencing on tumor-draining lymph nodes and tumor tissues from patients with colorectal cancer. Through in-depth analysis of the single-cell data, we established the connection betw

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12501088 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature