Effects of graded calorie restriction: XXII. Impact of long-term graded calorie restriction on tissue partitioning, digestive efficiency, bone health, and coordination in male C57BL/6J mice.

ABSTRACT: Calorie restriction (CR) is the reduction in calorie intake while avoiding malnutrition. CR increases longevity and attenuates the development of many age-related diseases, although some unfavorable responses have been reported. In response to CR, energy is withdrawn from tissues to correct the energy deficit. Changes in tissue mass over short-term, 3 months graded CR (STCR) were complex and while most tissues reduced size, some grew. Employing a graded long-term CR (LTCR) protocol in male C57BL/6J mice, tissue utilization, digestive efficiency, bone health and motor coordination was investigated. Mice were restricted by 10%-40% over 580 days/19 months and sacrificed at 24-month old. Control mice fed ad libitum in the 12-hr darkphase only (12AL) were regarded as 0CR. The patterns of tissue

SUBMITTER: Mitchell SE 

PROVIDER: S-EPMC12501111 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature