Disentangling metabolic and neurovascular timescales supporting cognitive processes.

ABSTRACT: The balance between neural excitation and inhibition (EIB), governed by glutamatergic and GABAergic neurotransmission, is an essential mechanism supporting cognitive processes. Yet, little is understood about how EIB shifts with engaging cognitive load and its impact on functional connectivity dynamics. Here, we combined time-resolved functional magnetic resonance spectroscopy and magnetic resonance imaging to investigate temporal profiles of the reciprocal modulation between EIB and functional network dynamics during working memory tasks in healthy subjects. We quantified EIB kinetics by measuring excitatory (Glx) and inhibitory (GABA+) levels and assessed their temporal coupling with dynamic functional connectivity states, revealing a dependence that scales with cognitive load. Notably,

SUBMITTER: Saviola F 

PROVIDER: S-EPMC12501135 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature