Integrating direct electrical stimulation with brain connectivity predicts lesion-induced language impairment and recovery.

ABSTRACT:

Background

Neurological conditions account for millions of deaths per year and induce long-lasting cognitive impairments. The disruption of structural brain networks predicts the emergence of cognitive impairments in stroke cases, but the role of the white matter in modeling longitudinal behavioral trajectories in glioma patients is understudied.

Methods

We analyzed 486 intracranial brain stimulations from 297 patients (age range 37-40, male ratio 53-64% depending on the functional categories) along with functional and structural brain connectivity data from over 1750 healthy individuals, to create a network mapping method able to identify the neural substrate causally involved in language production. We tested the validity of our procedure by (i) quantifying the spatial cor

SUBMITTER: Coletta L 

PROVIDER: S-EPMC12501223 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature