Reconfiguration of functional brain hierarchy in schizophrenia.

ABSTRACT: The multidimensional nature of schizophrenia requires a comprehensive exploration of the functional and structural brain networks. While prior research has provided valuable insights into these aspects, our study goes a step further to investigate the reconfiguration of the hierarchy of brain dynamics, which can help understand how brain regions interact and coordinate in schizophrenia. We applied an innovative thermodynamic framework, which allows for a quantification of the degree of functional hierarchical organisation by analysing resting state fMRI-data. Our findings reveal increased hierarchical organisation at the whole-brain level and within specific resting-state networks in individuals with schizophrenia, which correlated with negative symptoms, positive formal thought disorder a

SUBMITTER: Acero-Pousa I 

PROVIDER: S-EPMC12501247 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature