Design, synthesis, and antimicrobial evaluation of new triazole-tethered tetrazole hybrids via DNA gyrase inhibition.

ABSTRACT: To address the increasing Antimicrobial Resistance (AMR), we developed a library of triazole-tethered tetrazole derivatives using a multicomponent synthetic click chemistry strategy. It is well known that combining two or more types of pharmacophores into one molecule could afford a new entity with varied bioactivities. Considering this, the final products (6a-6o) were synthesized in excellent yields and were duly characterized using spectrometric analysis, including NMR and HRMS. To rationalize their biological attributes, synthetics were tested using different pathogenic microbial strains (S. aureus (ATCC 25923), S. epidermidis (ATCC 35984), E. coli (ATCC 25922), A. hydrophila (ATCC 7966), P. aeruginosa (ATCC 27853), S. typhi (Clinical isolate), S. typhimurium (Clinical isolate)). The an

SUBMITTER: Agarwal A 

PROVIDER: S-EPMC12501259 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature