The impact of interferon-γ pathway on trained immunity induction by vaccination with Bacille Calmette-Guerin.

ABSTRACT: Bacillus Calmette-Guérin (BCG) has multiple heterologous off-target effects which extend beyond tuberculosis (TB) prophylaxis, which include protection against other non-tuberculous infections, autoimmune diseases, and tumor development. These heterologous effects are at least partially mediated by induction of trained immunity. In this study, we aimed to investigate the impact of IFNγ production capacity on induction of trained immunity in human volunteers vaccinated with BCG. We evaluated inflammation and immune activation-specific cytokine responses (IFNγ, TNF, IL-1, and IL-6) in PBMCs isolated from 323 healthy volunteers vaccinated with BCG and stimulated with either Mycobacterium tuberculosis or Staphylococcus aureus. We further assessed the impact of genetic variants in genes crucial

SUBMITTER: Isachesku E 

PROVIDER: S-EPMC12501311 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature