Repeated ablations of mature Tmem10⁺ oligodendrocytes recapitulates key pathological features of multiple sclerosis with prolonged demyelination.

ABSTRACT: Managing multiple sclerosis (MS), a chronic, neuroinflammatory and demyelinating disease, remains an unmet medical need. A great obstacle to developing therapeutic interventions altering the disease process is the lack of a suitable disease model recapitulating its core pathologies, especially the process of myelin damage and regeneration against the backdrop of persistent neuroinflammation. Now we report the generation and characterization of a new demyelination/remyelination model with key pathological features of MS through repeated ablations of Tmem10⁺ oligodendrocytes. Using the Tmem10-Cre driver that targets expression of diphtheria toxin receptor (DTR) in Tmem10⁺ (mature myelin-forming) oligodendrocytes, we conducted 3 rounds of Tmem10⁺ oligodendrocy

SUBMITTER: Zhu F 

PROVIDER: S-EPMC12501313 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature