Pregnancy hypertension is associated with higher p-tau217 in healthy midlife women.

ABSTRACT:

Introduction

There is very limited knowledge on the relationship between pregnancy hypertension and the occurrence of pre-clinical Alzheimer's disease (AD).

Methods

Community-dwelling midlife women without dementia were enrolled from well-woman clinics of the National University Hospital, Singapore. Sociodemographic parameters and history of pregnancy hypertension were obtained. Cognition was assessed using the Montreal Cognitive Assessment-Basic tool. Fasted blood samples were stored for batched analysis of renal function, APOE genotyping and p-tau217 levels using Simoa® ALZpath p-tau217 Advantage PLUS (Quanterix, MA, USA). General linear modelling was used to examine the association between pregnancy hypertension and p-tau217.

Results

Among 743 women (mean age 62.9

SUBMITTER: Yong EL 

PROVIDER: S-EPMC12501320 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature