Dietary sugar intake, genetic susceptibility, and risk of dementia: A prospective cohort study.

ABSTRACT:

Background

Sugar intake has been identified as a risk factor for incident dementia; however, the role of genetic susceptibility in such association remains unclear.

Methods

This cohort study involved 158,408 participants from the UK Biobank to explore the effect of genetic susceptibility on the association between dietary sugar intake and dementia risk. Data on sugar intake were evaluated using repeated web-based 24-hour dietary recalls. Polygenic risk scores (PRS) for sugar metabolism (Triglyceride Glucose, TyG), gut microbiota, and disease susceptibility (Alzheimer's disease) were generated based on genome-wide association studies.

Results

Over a median follow-up period of 9.94 years, 1,219 dementia cases (0.7%) were documented. There were significant positive dose-

SUBMITTER: An Y 

PROVIDER: S-EPMC12501323 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature