A novel early imaging biomarker for glymphatic function: Cerebral cortical arterial pulsatility index from 2-Minute phase-contrast MRI.

ABSTRACT:

Background

Arterial pulsatility is one of the driving forces of glymphatic flow.

Objectives

To evaluate the feasibility of the pulsatility index (PI) of cortical arteries in the centrum semiovale (PI_CSO) as a novel non-invasive imaging biomarker for Alzheimer's disease (AD) in the context of glymphatic function.

Design

Retrospective cross-sectional study.

Setting

Single tertiary academic center equipped with both 3.0 T MRI systems.

Participants

A total of 160 individuals were enrolled: 50 healthy volunteers, 46 cognitively normal controls, and 64 AD patients who underwent diffusion tensor imaging (DTI) and 2D phase-contrast MRI.

Measurements

Diffusion Tensor Imaging Analysis along the Perivascular Space (DTI-ALPS) index and PI_CSO</

SUBMITTER: You SH 

PROVIDER: S-EPMC12501337 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature