Association of sugar intake with incident dementia in the UK Biobank: a prospective cohort study.

ABSTRACT:

Background

Excessive sugar intake has been implicated in increased dementia risk; however, existing studies are constrained by small sample sizes and a primary focus on total sugar, with limited investigation into specific sugar subtypes. This study explores the relationship between sugar intake, its subtypes, and the incidence of dementia.

Methods

We analyzed 172,516 participants from the UK Biobank who completed at least one 24-hour dietary recall (Oxford WebQ). Cox proportional hazards models estimated the hazard ratios (HRs) and 95 % confidence intervals (95 % CIs) for total sugar and its subtypes (free sugar, fructose, glucose, sucrose, maltose, lactose, and other sugars) about the risk of dementia. Sex-stratified analyses were also performed.

Results

Higher inta

SUBMITTER: Che Y 

PROVIDER: S-EPMC12501338 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature