Medical risk factors, ApoE haplotype, and Alzheimer's disease: a large-scale analysis.

ABSTRACT:

Background

The multifactorial nature of Alzheimer's disease (AD) has become increasingly evident. In addition to well-established features like neurodegeneration, amyloid-beta and tau deposition, or glial changes, other processes-such as metabolic, circulatory, and inflammatory factors-may also play a key role in driving or accelerating AD-related pathology and cognitive decline. These factors represent important targets for slowing disease progression.

Objectives

Although many studies have examined individual risk factors and meta-analyses have been performed, a large-scale, comprehensive comparison using formal medical data from a single, unified cohort is needed.

Design

A retrospective case-control study leveraging comprehensive health database.

Setting

Data

SUBMITTER: Elias U 

PROVIDER: S-EPMC12501343 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature