The involvement of 5-HT was necessary for EA-mediated improvement of post-stroke depression.

ABSTRACT: The prevalence of depression is as high as about 30% within five years after stroke, while there is still no breakthrough in the Western medical treatments for post-stroke depression (PSD) in clinical practice. The traditional acupuncture treatment has been practiced to be effective for the therapy of PSD, but its mechanism still needs to be elucidated. With a combination of methods, including behavioral testing, immunofluorescence, in vivo electrophysiological recording, mRNA sequencing, genetic modulation, and in vivo fiber recording techniques, this study showed that electroacupuncture (EA) at Baihui (GV20) and Shenting (GV24) acupoints improved the depressive-like behaviors and neuronal electrophysiological activities in PSD model mice, which was established by bilateral injection of c

SUBMITTER: Deng B 

PROVIDER: S-EPMC12501360 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature