TGR5 dysfunction underlies chronic social defeat stress via cAMP/PKA signaling pathway in the hippocampus.

ABSTRACT: Major depressive disorder (MDD) is a debilitating mental health disorder that has a wide impact on many patients and has imposed a heavy burden on society in recent years. However, the specific pathogenesis of depression remains to be elucidated. Numerous studies have shown that metabolic disorders and molecules play important roles in MDD. Here, we demonstrate a preliminary mechanism through which TGR5 functions in the hippocampus during bile acid synthesis dysfunction in mice subjected to chronic social defeat stress (CSDS). According to the enzyme-linked immunosorbent assay (ELISA), susceptible mice subjected to CSDS presented reduced expression of key bile acid enzymes in the serum and total bile acids (TBAs) in the hippocampus. The expression of the bile acid-related receptor TGR5 in

SUBMITTER: Chen X 

PROVIDER: S-EPMC12501386 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature