Associations Between Earlier Menarche and Fibroid Severity in Individuals Seeking Hysterectomy.

ABSTRACT: Objective: Early menarche is associated with uterine fibroid risk, but the association between menarcheal timing and fibroid severity remains to be explored. Given the hormonal dependence of fibroids, earlier menarche may increase physical burden (e.g., number of fibroids) and/or symptoms (e.g., heavy menstrual bleeding), though the two are not always correlated. We hypothesized that individuals with earlier menarche are more likely to have severe fibroids. Design: We analyzed observational data using linear regression models to examine the association between earlier age at menarche and fibroid severity. Subjects: Individuals seeking hysterectomy (n = 110) for fibroid management at a hospital in Washington, D.C. from 2014 to 2021 as part of the Fi

SUBMITTER: Siegel EL 

PROVIDER: S-EPMC12501415 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature