Double positivity for anti-dsDNA and anti-Sm antibodies represents higher disease activity in systemic lupus erythematosus.

ABSTRACT:

Background

Several studies have shown that anti-dsDNA and anti-Sm antibodies not only contribute to the classification of systemic lupus erythematosus (SLE) but also strongly correlate with disease activity. However, the relationship between double positivity for anti-dsDNA and anti-Sm antibodies and disease activity remains unclear.

Objectives

This study aimed to assess the clinical significance of double positivity for anti-dsDNA and anti-Sm antibodies in SLE.

Design

A single-center retrospective study was conducted, consecutively enrolled hospitalized patients with SLE who underwent anti-dsDNA and anti-Sm antibody testing between June 2009 and December 2022.

Methods

In this study, clinical data were collected from the electronic medical records of all study

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12501451 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature