Causal effect of serum lipopolysaccharide activity levels and inflammatory proteins on Alzheimer's disease: A Mendelian randomization study combined with meta-analysis in a large-scale cohort.

ABSTRACT:

Background

Neuroinflammation represents a central pathological mechanism in Alzheimer's disease (AD). Lipopolysaccharide (LPS) is a potent inducer of neuroinflammation and demonstrates elevated circulating levels in AD patients.

Objective

This study aims to investigate the genetic association between serum LPS activity level, inflammatory proteins and AD.

Methods

A two-sample mendelian randomization (MR) analysis was performed to explore the causal effect of serum LPS activity level and 91 inflammatory proteins on AD, including 1, 260, 136 sporadic AD and 2, 838, 825 familial AD patients, respectively. Meta-analysis was conducted on multiple datasets to determine statistically significant results that was initially observed in one dataset.

Results

Serum LPS act

SUBMITTER: Niu L 

PROVIDER: S-EPMC12501456 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature