Antihypertensive Drugs and Dental Caries Risk: A Drug-Target Mendelian Randomization Analysis.

ABSTRACT:

Introduction and objectives

To address the clinical uncertainty surrounding the effect of antihypertensive drugs on dental caries, this study was aimed at investigating the causal relationships between antihypertensive medication use and the risk of dental caries, utilizing a drug-target Mendelian randomization (MR) approach.

Methods

Nine antihypertensive drug classes' influences on dental caries risk in the UK Biobank and FinnGen populations were assessed using drug-target MR. This genetic method utilizes randomly allocated gene variants as proxies for drug exposure, minimizing the confounding biases inherent in observational studies and allowing for more robust causal inference. Genetic variants associated with systolic blood pressure near the drug target genes were used t

SUBMITTER: Shi W 

PROVIDER: S-EPMC12501493 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature