Susceptibility MRI Helps Predict Mild Cognitive Impairment Onset and Cognitive Decline in Cognitively Unimpaired Older Adults.

ABSTRACT: Background Elevated brain iron is a potential marker for neurodegeneration, but its role in predicting onset of mild cognitive impairment (MCI) and prospective cognitive trajectories remains unclear. Purpose To investigate how brain iron and amyloid-β (Aβ) levels, measured using quantitative susceptibility mapping (QSM) MRI and PET, help predict MCI onset and cognitive decline. Materials and Methods In this prospective study conducted between January 2015 and November 2022, cognitively unimpaired older adults underwent baseline QSM MRI. Among the majority with baseline PET data (PET subgroup), cortical Aβ burden was measured. Cox regression and linear mixed-effects models were used to examine associations between baseline tissue susceptibility and time to MCI onset and changes in cognitive

SUBMITTER: Chen L 

PROVIDER: S-EPMC12501624 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature