A Photon-Driven Unimolecular Immunostimulant for Self-Amplified Pyroptosis and cGAS-STING Pathway by Destroying the Pyroptosis Checkpoint.

ABSTRACT: Immunotherapy is a groundbreaking approach for clinically treating tumors, but its effectiveness is hindered by the tumor's immunosuppressive environment and lack of immune cell infiltration, enabling tumors to evade the immune system. Although the activation of both innate and adaptive immunities is a promising strategy to counteract this bottleneck, their synergy remains challenging. Therefore, we developed Bio-Cy, an unprecedented organic unimolecular photosensitive immunostimulant, which stimulates self-amplifying pyroptosis and cGAS-STING pathways by disrupting pyroptosis checkpoints to enhance adaptive and innate immunity activation. Mechanistic studies have shown that Bio-Cy can target cancer cells and be transported to lysosomes via endocytosis, generating reactive oxygen species t

SUBMITTER: Zeng S 

PROVIDER: S-EPMC12501661 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature