Evaluation of renal masses with CEST MRI: Protocol optimization and preliminary results.

ABSTRACT:

Purpose

This study investigates the application of CEST MRI in human kidneys, with the overarching goal of developing CEST MRI for renal mass characterization. Here, the focus is on the development of a protocol and the proof-of-principle evaluation of CEST for the characterization of clear cell renal cell carcinoma (ccRCC).

Methods

Ten healthy volunteers and five patients diagnosed with ccRCC underwent CEST MRI scans at 3 T. The sequence performance was characterized in healthy volunteers and tested using three saturation power levels, B_1rms = 0.7, 1.2, and 1.6 μT. We compared the magnetization transfer ratio asymmetry (MTR_asym) values at 1.0, 2.0, and 3.5 ppm between the kidney cortex of healthy volunteers and the cortex/renal masses of renal cell car

SUBMITTER: Wang X 

PROVIDER: S-EPMC12501682 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature