Electrochemical Point-of-Care Test for Assessing Serum Paracetamol Concentration: Comparison With Traditional Methods and Detection of Concomitant Drugs.

ABSTRACT: Rapid serum paracetamol (acetaminophen) concentration measurement is essential in suspected intoxication, but centralized laboratory analyses often delay initiation of antidotal therapy. We studied the feasibility of a novel electrochemical single-walled carbon nanotube/Nafion-based point-of-care (POC) method in detecting paracetamol in 99 suspected overdose patient serum samples. POC was compared with the standard photoelectric enzymatic method (PEM) and ultra-high performance liquid chromatography-photodiode array and corona-charged aerosol detector (UHPLC-DAD-CAD). We also analysed for 900 concomitant pharmaceuticals, drugs and chemicals in 197 samples with time-of-flight mass spectrometry to assess interference with paracetamol concentration measurements. Paracetamol concentrations mea

SUBMITTER: Kujala JK 

PROVIDER: S-EPMC12501696 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature