Quantitative macromolecular proton fraction imaging using pulsed spin-lock.

ABSTRACT:

Purpose

Recent studies have shown that spin-lock MRI can simplify quantitative magnetization transfer (MT) by eliminating its dependency on water pool parameters, removing the need for a T1 map in macromolecular proton fraction (MPF) quantification. However, its application is often limited by the requirement for long radiofrequency (RF) pulse durations, which are constrained by RF hardware capabilities despite remaining within specific absorption rate (SAR) safety limits.

Methods

To address this challenge, we propose a novel method, MPF mapping using pulsed spin-lock (MPF-PSL). MPF-PSL employs a pulsed spin-lock train with intermittent free precession periods, enabling extended total spin-lock durations without exceeding hardware and specific absorption rate limits. A compr

SUBMITTER: Shan Q 

PROVIDER: S-EPMC12501701 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature