Nuclear spin hyperpolarization of pyruvate enables longitudinal monitoring of treatment response in intestinal tumor organoids.

ABSTRACT:

Purpose

Colorectal cancer, a leading cause of death in the Western world, is increasingly affecting younger populations. The Warburg effect, characterized by enhanced lactate production, is a hallmark of this cancer type. Although ¹⁸F-FDG PET-CT is commonly used for diagnosis, MRI offers higher spatial and chemical resolution without the drawbacks of radiation. However, MRI's low sensitivity has been a barrier to real-time metabolic imaging, and hence its implementation in clinical practice. Hyperpolarization has significantly boosted NMR sensitivity, enabling detailed metabolic studies in vivo.

Methods

This study uses hyperpolarized [1-¹³C]pyruvate with dissolution dynamic nuclear polarization to noninvasively monitor metabolic changes in intestinal or

SUBMITTER: Peters JP 

PROVIDER: S-EPMC12501731 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature