Assessing cerebral microvascular pulsatility using flow pulsatile-resolved pseudo-continuous arterial spin labeling MRI.

ABSTRACT:

Purpose

To develop a flow pulsatile-resolved pseudo-continuous arterial spin labeling (FPR-pCASL) technique for noninvasively assessing cerebral microvascular pulsatility.

Methods

In FPR-pCASL, a pCASL sequence with single-shot three-dimensional gradient and spin echo acquisition was performed while simultaneously recording cardiac pulse signals using a pulse oximeter, and the pCASL images were retrospectively binned into multiple cardiac phases to resolve pulsatile microvascular blood flow. Both numerical simulations and in vivo experiments were performed to investigate the confounding factors of cardiac-induced variations of labeling efficiency and arterial transit time on pCASL signal fluctuations. An in vivo experiment was conducted to examine and optimize the postlabeli

SUBMITTER: Zhao T 

PROVIDER: S-EPMC12501735 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature