Dynamic contrast enhanced-magnetic resonance fingerprinting (DCE-MRF): A new quantitative MRI method to reliably assess tumor vascular perfusion.

ABSTRACT:

Purpose

The clinical utility of conventional DCE-MRI methods is limited by the use of conventional qualitative dynamic T₁-weighted images, resulting in poor reproducibility. This study presents the initial implementation of a new DCE-magnetic resonance fingerprinting (DCE-MRF) methodology to provide reproducible, quantitative assessments of tumor vascular perfusion.

Methods

The DCE-MRF acquisition combines multiple T₁ preparations, highly undersampled spiral trajectories (R = 48), a low-rank reconstruction method, and low tip angles on a 9.4 T preclinical MRI scanner to rapidly generate dynamic T₁ maps (23-s temporal resolution). In vitro validation experiments were conducted across a range of Gadovist concentrations to assess accuracy and te

SUBMITTER: MacAskill CJ 

PROVIDER: S-EPMC12501753 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature